Friday, October 7, 2016

Hibistat


Generic Name: chlorhexidine topical (klor HEX i deen TOP i kal)

Brand Names: Betasept, Biopatch, Calgon Vesta, Chlorostat, Chlorostat 4, Dyna-Hex, Hibiclens, PerioChip, Spectrum-4


What is Hibistat (chlorhexidine topical)?

Chlorhexidine is an antiseptic that fights bacteria.


Chlorhexidine topical (for the skin) is used to clean the skin to prevent infection that may be caused by surgery, injection, or skin injury.


Chlorhexidine topical may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Hibistat (chlorhexidine topical)?


You should not use chlorhexidine topical if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to use chlorhexidine topical if you have any allergies to food, dyes, animals, or medicines.


Avoid getting this medication in your eyes, ears, nose, mouth, rectum, or vagina. Chlorhexidine topical is for use only on the skin.

Stop using the medication and call your doctor if you have a skin reaction such as severe burning, itching, redness, blistering, peeling, swelling, rash, or any other severe irritation.


What should I discuss with my health are provider before using Hibistat (chlorhexidine topical)?


You should not use chlorhexidine topical if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have any allergies to food, dyes, animals, or medicines.


FDA pregnancy category C. It is not known whether chlorhexidine topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether chlorhexidine topical passes into breast milk or if it could harm a nursing baby. Do not breast-feed if you are using this medicine to treat a skin condition in the breast area. Chlorhexidine topical should not be used on a child younger than 2 months old.

How should I use Hibistat (chlorhexidine topical)?


Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.


Rinse the skin before applying chlorhexidine topical gel or dressing. Apply only enough to cover the area you are treating.


To use chlorhexidine topical soap, apply only enough to cover the area you are treating. Wash the area gently, then rinse thoroughly with plain water. Avoid using over large areas of skin.


Do not apply this medication to deep cuts, scrapes, or open skin wounds. Chlorhexidine topical can also be harmful if it gets in your eyes, ears, mouth, nose, rectum, or vagina.

Call your doctor if your symptoms do not improve, or if they get worse while using chlorhexidine topical.


Some forms of this medicine are flammable. Do not use while you are smoking, or near high heat or open flame. Store at room temperature away from moisture, heat, and light. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?


Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Hibistat (chlorhexidine topical)?


Avoid getting this medication in your eyes, ears, nose, mouth, rectum, or vagina. If this does happen, rinse with water. Chlorhexidine topical is for use only on the skin.

Avoid using other medications on the areas you treat with chlorhexidine topical unless you doctor tells you to.


Avoid getting this medication on your clothing or other fabrics. Do not use bleach to wash any fabric exposed to chlorhexidine or the medicine may cause a permanent stain.


Hibistat (chlorhexidine topical) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using chlorhexidine topical and call your doctor at once if you have a serious side effect such as:

  • severe burning, itching, or redness;




  • blistering or peeling;




  • swelling or severe skin rash; or




  • any other severe irritation of treated skin.



Less serious side effects may occur, and you may have none at all.


This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Hibistat (chlorhexidine topical)?


It is not likely that other drugs you take orally or inject will have an effect on topically applied chlorhexidine topical. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Hibistat resources


  • Hibistat Side Effects (in more detail)
  • Hibistat Use in Pregnancy & Breastfeeding
  • Hibistat Support Group
  • 0 Reviews for Hibistat - Add your own review/rating


  • Hibistat Advanced Consumer (Micromedex) - Includes Dosage Information

  • Betasept Liquid MedFacts Consumer Leaflet (Wolters Kluwer)

  • Peridex Prescribing Information (FDA)

  • Peridex Advanced Consumer (Micromedex) - Includes Dosage Information

  • Peridex Solution MedFacts Consumer Leaflet (Wolters Kluwer)

  • PerioGard Prescribing Information (FDA)

  • Periochip Prescribing Information (FDA)



Compare Hibistat with other medications


  • Gingivitis
  • Mucositis
  • Periodontitis


Where can I get more information?


  • Your pharmacist can provide more information about chlorhexidine topical.

See also: Hibistat side effects (in more detail)


Hongos


Generic Name: tolnaftate topical (toll NAF tate)

Brand Names: Absorbine Athletes Foot, Absorbine Jr. Antifungal, Aftate For Athletes Foot, Blis-To-Sol, Desenex Spray, Fungatin, Fungi-Guard, Genaspor, Hongos, NP 27, Podactin, T-Athlete, Tinactin, Tinaspore, Ting


What is Hongos (tolnaftate topical)?

Tolnaftate topical is an antifungal medication. Tolnaftate topical prevents fungus from growing on the skin.


Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.


Tolnaftate topical may also be used for purposes other than those listed in this medication guide.


What is the most important information I should know about Hongos (tolnaftate topical)?


Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

Do not use bandages or dressings that do not allow air to circulate to the affected area (occlusive dressings) unless otherwise directed by your doctor. Wear loose-fitting clothing (preferably cotton).


Avoid getting this medication in the eyes, nose, or mouth.

What should I discuss with my healthcare provider before using Hongos (tolnaftate topical)?


Do not use tolnaftate topical if you have had an allergic reaction to it in the past.


It is not known whether tolnaftate topical will be harmful to an unborn baby. Do not use tolnaftate topical without first talking to your doctor if you are pregnant. It is not known whether tolnaftate topical passes into breast milk. Do not use tolnaftate topical without first talking to your doctor if you are breast-feeding a baby.

How should I use Hongos (tolnaftate topical)?


Use tolnaftate topical exactly as directed by your doctor or follow the directions that accompany the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after using this medication.


Clean and dry the affected area. Apply the gel, cream, lotion, spray, or powder twice daily as directed for 2 to 6 weeks.


Use this medication for the full amount of time prescribed by your doctor or as recommended in the package even if you begin to feel better. Your symptoms may improve before the infection is completely healed.

If the infection does not clear up in 10 days or if it appears to get worse, see your doctor.


Do not use bandages or dressings that do not allow air circulation over the affected area (occlusive dressings) unless otherwise directed by your doctor. A light cotton-gauze dressing may be used to protect clothing.


Avoid getting this medication in the eyes, nose, or mouth. Store tolnaftate topical at room temperature away from moisture and heat.

What happens if I miss a dose?


Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the dose you missed and apply only the regular amount of tolnaftate topical. Do not use a double dose unless otherwise directed by your doctor.


What happens if I overdose?


An overdose of tolnaftate topical is unlikely to occur. If you do suspect that a much larger than normal dose has been used or that tolnaftate topical has been ingested, contact an emergency room or a poison control center.


What should I avoid while using Hongos (tolnaftate topical)?


Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until the infection is healed.


Hongos (tolnaftate topical) side effects


Serious side effects of tolnaftate topical use are not expected to occur. Stop using tolnaftate topical and see your doctor if you experience unusual or severe blistering, itching, redness, peeling, dryness, or irritation of the skin.


Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Hongos (tolnaftate topical)?


Other skin medications may affect the absorption or effectiveness of tolnaftate topical. Avoid using other topicals at the same time except under the direction of a doctor.



More Hongos resources


  • Hongos Side Effects (in more detail)
  • Hongos Use in Pregnancy & Breastfeeding
  • Hongos Support Group
  • 0 Reviews for Hongos - Add your own review/rating


  • Absorbine Jr. Antifungal Topical Advanced Consumer (Micromedex) - Includes Dosage Information

  • Blis-To-Sol Powder MedFacts Consumer Leaflet (Wolters Kluwer)

  • Desenex Spray MedFacts Consumer Leaflet (Wolters Kluwer)

  • Tinactin Cream MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Hongos with other medications


  • Tinea Corporis
  • Tinea Cruris
  • Tinea Pedis
  • Tinea Versicolor


Where can I get more information?


  • Your pharmacist has additional information about tolnaftate topical written for health professionals that you may read.

See also: Hongos side effects (in more detail)


Homatropaire


Generic Name: atropine, homatropine, and scopolamine (Ophthalmic route)


Commonly used brand name(s)

In the U.S.


  • AK-Dilate

  • AK-Pentolate

  • Altafrin

  • Atropine Care

  • Cyclogyl

  • Cyclomydril

  • Eye Cool

  • Homatropaire

  • Isopto Atropine

  • Isopto Homatropine

  • Isopto Hyoscine

  • Mydfrin

  • Mydral

  • Mydriacyl

  • Neofrin

  • Neo-Synephrine

  • Paremyd

In Canada


  • Ak-Dilate

  • Ak-Pentolate

  • Atropine

  • Atropine-Ak

  • Atropine Eye Ointment

  • Atropine Ointment

  • Atropisol

  • Minims Phenylephrine Hydrochloride

Available Dosage Forms:


  • Ointment

  • Solution

Uses For Homatropaire


Ophthalmic atropine, homatropine, and scopolamine are used to dilate (enlarge) the pupil of the eye. They are used before eye examinations, before and after eye surgery, and to treat certain eye conditions, such as uveitis or posterior synechiae.


These medicines are available only with your doctor's prescription.


Before Using Homatropaire


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Infants and young children and children with blond hair or blue eyes may be especially sensitive to the effects of atropine, homatropine, or scopolamine. This may increase the chance of side effects during treatment . Children should use a lower strength of this medicine.


Geriatric


Elderly people are especially sensitive to the effects of atropine, homatropine, or scopolamine. This may increase the chance of side effects during treatment.


Pregnancy


Studies on effects in pregnancy have not been done in either humans or animals. However, these medicines may be absorbed into the body.


Breast Feeding


These medicines may be absorbed into the body. Atropine passes into the breast milk in very small amounts and may cause side effects, such as fast pulse, fever, or dry skin, in babies of nursing mothers using ophthalmic atropine. It is not known whether homatropine or scopolamine passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are using one of these medicines and who wish to breast-feed should discuss this with their doctor.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.


Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:


  • Brain damage (in children) or

  • Down's syndrome (mongolism) (in children and adults) or

  • Glaucoma or

  • Other eye diseases or problems or

  • Spastic paralysis (in children)—Use of ophthalmic atropine, homatropine, or scopolamine may make the condition worse.

Proper Use of atropine, homatropine, and scopolamine

This section provides information on the proper use of a number of products that contain atropine, homatropine, and scopolamine. It may not be specific to Homatropaire. Please read with care.


To use the ophthalmic solution (eye drops) form of this medicine:


  • First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 2 or 3 minutes to allow the medicine to be absorbed by the eye.

  • Immediately after using the eye drops, wash your hands to remove any medicine that may be on them. If you are using the eye drops for an infant or child, be sure to wash his or her hands immediately afterwards also, and do not let any of the medicine get in his or her mouth. In addition, wipe off any medicine that may have accidentally gotten on the infant or child, including his or her face or eyelids.

  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.

To use the ointment form of this medicine:


  • First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Squeeze a thin strip of ointment into this space. A 1/3- to ½;-cm (approximately ⅛-inch in infants and young children and ¼-inch in older children and adults) strip of ointment is usually enough, unless you have been told by your doctor to use a different amount. Let go of the eyelid and gently close the eyes. Keep the eyes closed for 1 or 2 minutes to allow the medicine to be absorbed by the eye.

  • Immediately after using the eye ointment, wash your hands to remove any medicine that may be on them. If you are using the eye ointment for an infant or child, be sure to wash his or her hands immediately afterwards also, and do not let any of the medicine get in his or her mouth. In addition, wipe off any medicine that may have accidentally gotten on the infant or child, including his or her face or eyelids.

  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). After using the eye ointment, wipe the tip of the ointment tube with a clean tissue and keep the tube tightly closed.

Use this medicine only as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of too much medicine being absorbed into the body and the chance of side effects. This is especially important when this medicine is used in infants and children, since overdose is very dangerous in infants and children.


Dosing


The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For atropine

  • For ophthalmic ointment dosage form:
    • For uveitis:
      • Adults—Use a thin strip of the ointment in the eye one or two times a day.

      • Children—Use a thin strip of the ointment in the eye one to three times a day.


    • For eye examinations:
      • Adults—Use and dose must be determined by your doctor.

      • Children—Use a thin strip of the ointment in the eye three times a day for one to three days before the examination.



  • For ophthalmic solution (eye drops) dosage form:
    • For uveitis:
      • Adults—Use one drop in the eye one or two times a day.

      • Children—Use one drop in the eye one to three times a day.


    • For eye examinations:
      • Adults—Use and dose must be determined by your doctor.

      • Children—Use one drop in the eye two times a day for one to three days before the examination.



  • For homatropine

  • For ophthalmic solution (eye drops) dosage form:
    • For uveitis:
      • Adults and children—Use 1 or 2 drops in the eye two or three times a day.


    • For eye examinations:
      • Adults—Use 1 or 2 drops in the eye. May be repeated every five to ten minutes for two or three doses.

      • Children—Use 1 or 2 drops in the eye every ten minutes for two or three doses.



  • For scopolamine

  • For ophthalmic solution (eye drops) dosage form:
    • For uveitis:
      • Adults and children—Use one drop in the eye up to four times a day.


    • For eye examinations:
      • Adults—Use one drop in the eye one hour before the examination.

      • Children—Use one drop in the eye two times a day for two days before the examination.


    • For posterior synechiae:
      • Adults—Use one drop in the eye every ten minutes for three doses.

      • Children—Use and dose must be determined by your doctor.


    • For use before and after surgery:
      • Adults and children—Use one drop in the eye one to four times a day.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


If you miss a dose of this medicine and your dosing schedule is:


  • One dose a day—Apply the missed dose as soon as possible. However, if you do not remember the missed dose until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

  • More than one dose a day—Apply the missed dose as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage


Keep out of the reach of children.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Do not keep outdated medicine or medicine no longer needed.


Precautions While Using Homatropaire


After you apply this medicine to your eyes:


  • Your pupils will become unusually large and you will have blurring of vision, especially for close objects. Make sure your vision is clear before you drive, use machines, or do anything else that could be dangerous if you are not able to see well.

  • Your eyes will become more sensitive to light than they are normally. Wear sunglasses to protect your eyes from sunlight and other bright lights.

These effects may continue for several days after you stop using this medicine. However, check with your doctor if they continue longer than:


  • 14 days if you are using atropine.

  • 3 days if you are using homatropine.

  • 7 days if you are using scopolamine.

Homatropaire Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Symptoms of too much medicine being absorbed into the body
  • Clumsiness or unsteadiness

  • confusion or unusual behavior

  • dryness of skin

  • fast or irregular heartbeat

  • fever

  • flushing or redness of face

  • seeing, hearing, or feeling things that are not there

  • skin rash

  • slurred speech

  • swollen stomach in infants

  • thirst or unusual dryness of mouth

  • unusual drowsiness, tiredness, or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Blurred vision

  • brief burning or stinging of the eyes

  • eye irritation not present before use of this medicine

  • increased sensitivity of eyes to light

  • swelling of the eyelids

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



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Hivid


Generic Name: zalcitabine (zal SITE ta been)

Brand Names: Hivid


What is Hivid (zalcitabine)?

Zalcitabine is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body.


Zalcitabine is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Zalcitabine is not a cure for HIV or AIDS.


Zalcitabine may also be used for purposes other than those listed in this medication guide.


What is the most important information I should know about Hivid (zalcitabine)?


Zalcitabine may cause lactic acidosis (the build up of lactic acid in the body). Lactic acidosis symptoms can start slowly and gradually get worse. Symptoms include unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, nausea, vomiting, stomach pain, and numbness or cold feeling in your arms or legs. Call your doctor at once if you have any of these symptoms, even if they are only mild. Early signs of lactic acidosis generally get worse over time and this condition can be fatal. Zalcitabine can also cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have any of these symptoms while taking zalcitabine: severe pain in your upper stomach spreading to your back, fast heart rate, nausea and vomiting, diarrhea, loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Before taking this medication, tell your doctor if you have kidney disease, liver disease, a history of pancreatitis, or if you have used a medicine similar to zalcitabine in the past, such as abacavir (Ziagen), didanosine (Videx), lamivudine (Epivir), stavudine (Zerit), tenofovir (Viread), or zidovudine (Retrovir).

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.


Taking zalcitabine will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.


What should I discuss with my healthcare provider before taking Hivid (zalcitabine)?


Do not use this medication if you are allergic to zalcitabine. Before taking this medication, tell your doctor if you are allergic to any drugs, or if you have:
  • kidney disease;

  • liver disease (including hepatitis B);


  • a history of pancreatitis; or




  • if you have used a medicine similar to zalcitabine in the past, such as abacavir (Ziagen), didanosine (Videx), lamivudine (Epivir), stavudine (Zerit), tenofovir (Viread), or zidovudine (Retrovir).



If you have any of the conditions listed above, you may not be able to use zalcitabine or you may need a dosage adjustment or special tests during treatment.


Zalcitabine may cause lactic acidosis (the build up of lactic acid in the body). Lactic acidosis symptoms can start slowly and gradually get worse. Symptoms include unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, nausea, vomiting, stomach pain, and numbness or cold feeling in your arms or legs. Call your doctor at once if you have any of these symptoms, even if they are only mild. Early signs of lactic acidosis generally get worse over time and this condition can be fatal. Zalcitabine can also cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have any of these symptoms while taking zalcitabine: severe pain in your upper stomach spreading to your back, fast heart rate, nausea and vomiting, diarrhea, loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. HIV can be passed to the baby if the mother is not properly treated during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Take all of your HIV medicines as directed to control your infection while you are pregnant.

Your name may need to be listed on an antiviral pregnancy registry when you start using zalcitabine. The purpose of this registry is to track the outcome of the pregnancy and delivery to evaluate whether zalcitabine had any effect on the baby.


You should not breast-feed while you are using zalcitabine. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk.

How should I take Hivid (zalcitabine)?


Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.


Take zalcitabine with a full glass of water.

Zalcitabine is usually taken every 8 hours, but if you have kidney disease you may need to take it every 12 or 24 hours. Follow your doctor's instructions.


Take zalcitabine on an empty stomach, at least 1 hour before or 2 hours after a meal. This will make it easier for your body to absorb the medicine.

It is important to use zalcitabine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.


HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.


To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.


Store zalcitabine in a tightly closed container at room temperature away from moisture and heat.

See also: Hivid dosage (in more detail)

What happens if I miss a dose?


Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a zalcitabine overdose may include nausea or drowsiness.


What should I avoid while taking Hivid (zalcitabine)?


Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Antacids contain different medicines and some types can make it harder for your body to absorb zalcitabine.


Avoid drinking alcohol while taking zalcitabine. Alcohol may increase the risk of damage to the pancreas and/or liver.

Taking zalcitabine will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.


Hivid (zalcitabine) side effects


Stop using zalcitabine and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these other serious side effects:



  • liver damage - nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);




  • lactic acidosis - muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, nausea with vomiting, and fast or uneven heart rate;




  • pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;




  • peripheral neuropathy - numbness, tingling, or pain in your hands or feet;




  • easy bruising or bleeding, unusual weakness, pale skin;




  • white patches or sores inside your mouth or on your lips;




  • seizure (convulsions);




  • fever, chills, body aches, flu symptoms; or




  • any other signs of new infection.



Less serious side effects may be more likely to occur, such as:



  • mild nausea, vomiting, stomach pain, diarrhea, constipation;




  • headache, tired feeling;




  • skin rash; or




  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and trunk).



Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.


What other drugs will affect Hivid (zalcitabine)?


Before taking zalcitabine, tell your doctor if you are using any of the following drugs:



  • cimetidine (Tagamet);




  • foscarnet (Foscavir);




  • nitrofurantoin (Furadantin, Macrobid, Macrodantin);




  • probenecid (Benemid);




  • amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet);




  • an antibiotic such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Mycifradin, Neo-Fradin, Neo-Tab), netilmicin (Netromycin), streptomycin, tobramycin (Nebcin, Tobi); or




  • other drugs that can affect the pancreas, such as asparaginase (Elspar), azathioprine (Imuran), estrogens (birth control or hormone replacement), furosemide (Lasix), methyldopa (Aldomet), pentamidine (Nebupent), sulindac, valproic acid (Depakene), diuretics (water pills), sulfa drugs, or tetracycline antibiotics.



If you are using any of these drugs, you may not be able to use zalcitabine, or you may need dosage adjustments or special tests during treatment.


There may be other drugs not listed that can affect zalcitabine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



More Hivid resources


  • Hivid Side Effects (in more detail)
  • Hivid Dosage
  • Hivid Use in Pregnancy & Breastfeeding
  • Drug Images
  • Hivid Drug Interactions
  • Hivid Support Group
  • 0 Reviews for Hivid - Add your own review/rating


  • Hivid Prescribing Information (FDA)

  • Hivid Advanced Consumer (Micromedex) - Includes Dosage Information

  • Hivid MedFacts Consumer Leaflet (Wolters Kluwer)

  • HIVID Monograph (AHFS DI)



Compare Hivid with other medications


  • HIV Infection


Where can I get more information?


  • Your pharmacist has information about zalcitabine written for health professionals that you may read.

What does my medication look like?


Zalcitabine is available with a prescription under the brand name Hivid. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.



  • Hivid 0.375 mg--oval, beige, film-coated tablets




  • Hivid 0.750 mg--oval, gray, film-coated tablets



See also: Hivid side effects (in more detail)


Histinex PV Liquid


Pronunciation: klor-fen-EER-a-meen/hye-droe-KOE-done/sue-do-eh-FED-rin
Generic Name: Chlorpheniramine/Hydrocodone/Pseudoephedrine
Brand Name: Generic only. No brands available.


Histinex PV Liquid is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.


Histinex PV Liquid is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex, which reduces a dry cough.


Do NOT use Histinex PV Liquid if:


  • you are allergic to any ingredient in Histinex PV Liquid or any other codeine- or morphine-related medicine (eg, codeine)

  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

  • you are unable to urinate or are having an asthma attack

  • you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Histinex PV Liquid:


Some medical conditions may interact with Histinex PV Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a fast, slow, or irregular heartbeat, heart blood vessel problems, or other heart problems

  • if you have a history of adrenal gland problems (eg, adrenal gland tumor); high blood pressure; diabetes; stroke; glaucoma; a blockage of your bladder, stomach, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; or an overactive thyroid

  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

  • if you have or recently have had any head or brain injury, brain tumor, increased pressure in the brain, infection of the brain or nervous system, epilepsy, or seizures

  • if you have a history of stomach problems (eg, ulcers), bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent abdominal surgery

  • if you have a history of alcohol or substance abuse or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Histinex PV Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Histinex PV Liquid's side effects

  • Cimetidine, digoxin, droxidopa, or sodium oxybate (GHB) because the risk of severe drowsiness, breathing problems, seizures, irregular heartbeat, or heart attack may be increased

  • Naltrexone because it may decrease Histinex PV Liquid's effectiveness

  • Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Histinex PV Liquid

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Histinex PV Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Histinex PV Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Histinex PV Liquid:


Use Histinex PV Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Histinex PV Liquid by mouth with or without food.

  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • If you miss a dose of Histinex PV Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Histinex PV Liquid.



Important safety information:


  • Histinex PV Liquid may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Histinex PV Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not take diet or appetite control medicines while you take Histinex PV Liquid without checking with your doctor.

  • Histinex PV Liquid has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.

  • Histinex PV Liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Histinex PV Liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Histinex PV Liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Histinex PV Liquid for a few days before the tests.

  • Tell your doctor or dentist that you take Histinex PV Liquid before you receive any medical or dental care, emergency care, or surgery.

  • Use Histinex PV Liquid with caution in the ELDERLY; they may be more sensitive to its effects.

  • Caution is advised when using Histinex PV Liquid in CHILDREN; they may be more sensitive to its effects.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Histinex PV Liquid while you are pregnant. It is not known if Histinex PV Liquid is found in breast milk. Do not breast-feed while taking Histinex PV Liquid.

When used for long periods of time or at high doses, Histinex PV Liquid may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Histinex PV Liquid stops working well. Do not take more than prescribed.


When used for longer than a few weeks or at high doses, some people develop a need to continue taking Histinex PV Liquid. This is known as DEPENDENCE or addiction.


If you suddenly stop taking Histinex PV Liquid, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; trouble sleeping.



Possible side effects of Histinex PV Liquid:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor; trouble sleeping; vision changes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Histinex PV side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Histinex PV Liquid:

Store Histinex PV Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Histinex PV Liquid out of the reach of children and away from pets.


General information:


  • If you have any questions about Histinex PV Liquid, please talk with your doctor, pharmacist, or other health care provider.

  • Histinex PV Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Histinex PV Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Histinex PV resources


  • Histinex PV Side Effects (in more detail)
  • Histinex PV Use in Pregnancy & Breastfeeding
  • Histinex PV Drug Interactions
  • Histinex PV Support Group
  • 0 Reviews for Histinex PV - Add your own review/rating


Compare Histinex PV with other medications


  • Cough and Nasal Congestion

Histatab Plus


Generic Name: chlorpheniramine and phenylephrine (KLOR fen IR a meen and FEN il EFF rin)

Brand Names: Allan Tannate Pediatric, Allerest PE, AlleRx, BP Allergy JR, C Phen, C Phen Drops, Cardec, Cardec Drops, Ceron, Ceron Drops, Chlor-Mes Jr, ChlorTan D, Cold & Allergy Relief, CP Dec, CP Dec Drops, Dallergy Drops, Dallergy-JR, Ed A-Hist, Ed ChlorPed D, Histadec, Nasohist Pediatric, NoHist, Ny-Tannic, PD-Hist D, PD-Hist D Drops, PediaTan D, Phenchlor Tannate Pediatric, R-Tanna, Relera, Rescon-Jr, Rinate Pediatric, Rondec, Rondec Drops, Rondex, Rondex Drops, Ry-Tann, Rynatan, Rynatan Pediatric, Sildec-PE, Sildec-PE Drops, Sinus & Allergy Maximum Strength, Sinus & Allergy PE, Sonahist, Sudafed PE Sinus & Allergy, Tanahist-D, Tannate Pediatric, Triaminic Cold & Allergy


What is Histatab Plus (chlorpheniramine and phenylephrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


The combination of chlorpheniramine and phenylephrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.


Chlorpheniramine and phenylephrine may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about Histatab Plus (chlorpheniramine and phenylephrine)?


There are many brands and forms of this medication available and not all brands are listed on this leaflet.


Do not use chlorpheniramine and phenylephrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Dangerous side effects may occur if you take chlorpheniramine and phenylephrine before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to chlorpheniramine or phenylephrine, or if you have severe high blood pressure or coronary artery disease, narrow-angle glaucoma, a stomach ulcer, or if you are unable to urinate.

Do not use this medication during an asthma attack.


This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of chlorpheniramine and phenylephrine. Older adults may be more likely to have side effects from this medicine. Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Contact your doctor if your symptoms do not improve or if they get worse after taking this medicine for 7 days.


What should I discuss with my healthcare provider before taking Histatab Plus (chlorpheniramine and phenylephrine)?


Do not use chlorpheniramine and phenylephrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Dangerous side effects may occur if you take chlorpheniramine and phenylephrine before the MAO inhibitor has cleared from your body. Do not use this medication if you are allergic to chlorpheniramine or phenylephrine, or if you have:

  • severe or uncontrolled high blood pressure;




  • severe coronary artery disease;




  • narrow angle glaucoma;




  • a stomach ulcer; or




  • if you are unable to urinate.



Do not use this medication during an asthma attack.


Ask a doctor or pharmacist if it is safe for you to take this medication if you have:


  • kidney disease;

  • liver disease;


  • diabetes;




  • glaucoma;




  • circulation problems;




  • heart disease or high blood pressure;




  • overactive thyroid;




  • a seizure disorder such as epilepsy;




  • asthma, emphysema or chronic bronchitis; or




  • urination problems or an enlarged prostate.




FDA pregnancy category C. It is not known whether chlorpheniramine and phenylephrine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether chlorpheniramine and phenylephrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.

How should I take Histatab Plus (chlorpheniramine and phenylephrine)?


Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.


Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take this medicine with a full glass of water. Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

The chewable tablet must be chewed before swallowing.


Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.


Contact your doctor if your symptoms do not improve or if they get worse after taking this medicine for 7 days.


Store chlorpheniramine and phenylephrine at room temperature away from moisture and heat.

What happens if I miss a dose?


Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose can cause nausea, vomiting, diarrhea, stomach pain, problems with balance or coordination, headache, urination problems, dizziness, feeling excited or irritable, hallucinations (seeing things), metallic taste in your mouth, tremors, fever, flushed face, and seizure (convulsions).


What should I avoid while taking Histatab Plus (chlorpheniramine and phenylephrine)?


This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of chlorpheniramine and phenylephrine.

Avoid using other medicines that may cause restlessness (such as caffeine, stimulants, diet pills, and decongestants contained in over-the-counter cold medicines). They can add to the stimulant effects of phenylephrine.


Histatab Plus (chlorpheniramine and phenylephrine) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using chlorpheniramine and phenylephrine and call your doctor at once if you have any of these serious side effects:

  • fast or uneven heart beats;




  • feeling light-headed, fainting;




  • seizure (convulsions);




  • hallucinations (seeing things that are not there); or




  • tremors.



Less serious side effects may include:



  • heartburn, nausea, vomiting, diarrhea, loss of appetite;




  • dry nose or mouth;




  • drowsiness, dizziness, weakness, headache;




  • dry eyes, blurred vision;




  • painful or difficult urination;




  • sleep problems (insomnia);




  • feeling nervous or excited (especially in children).



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Histatab Plus (chlorpheniramine and phenylephrine)?


Sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by chlorpheniramine. Tell your doctor if you regularly use any of these medicines, or any other cold or allergy medications..

Tell your doctor about all other medications you use, especially:



  • mecamylamine (Inversine);




  • methyldopa (Aldomet);




  • reserpine;




  • a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;




  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or




  • an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others.



This list is not complete and there may be other drugs that can interact with chlorpheniramine and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



More Histatab Plus resources


  • Histatab Plus Side Effects (in more detail)
  • Histatab Plus Use in Pregnancy & Breastfeeding
  • Histatab Plus Drug Interactions
  • Histatab Plus Support Group
  • 0 Reviews for Histatab Plus - Add your own review/rating


  • AlleRx Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

  • Cardec Drops MedFacts Consumer Leaflet (Wolters Kluwer)

  • Dallergy-JR Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

  • Ny-Tannic MedFacts Consumer Leaflet (Wolters Kluwer)

  • Relera Controlled-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Rondec MedFacts Consumer Leaflet (Wolters Kluwer)

  • Rynatan Prescribing Information (FDA)

  • Sonahist Prescribing Information (FDA)



Compare Histatab Plus with other medications


  • Cold Symptoms
  • Hay Fever


Where can I get more information?


  • Your pharmacist can provide more information about chlorpheniramine and phenylephrine.

See also: Histatab Plus side effects (in more detail)


Histex HC Liquid


Pronunciation: car-bihn-OCKS-ah-meen/hye-droe-KOE-done/sue-do-eh-FED-rin
Generic Name: Carbinoxamine/Hydrocodone/Pseudoephedrine
Brand Name: Examples include Histex HC and Mintex HC


Histex HC Liquid is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory tract infections, and allergies. It may also be used for other conditions as determined by your doctor.


Histex HC Liquid is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex, which reduces a dry cough.


Do NOT use Histex HC Liquid if:


  • you are allergic to any ingredient in Histex HC Liquid or any other codeine- or morphine-related medicine (eg, codeine)

  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

  • you are unable to urinate or are having an asthma attack

  • you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Histex HC Liquid:


Some medical conditions may interact with Histex HC Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a fast, slow, or irregular heartbeat, blood vessel problems, or other heart problems

  • if you have a history of adrenal gland problems (eg, adrenal gland tumor); high blood pressure; diabetes; stroke; glaucoma; a blockage of your bladder, stomach, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; or an overactive thyroid

  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

  • if you have a history of head or brain injury, brain tumor, increased pressure in the brain, infection of the brain or nervous system, epilepsy, or seizures

  • if you have a history of stomach problems (eg, ulcers), bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent abdominal surgery

  • if you have a history of alcohol or substance abuse or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Histex HC Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because the side effects of Histex HC Liquid may be increased

  • Cimetidine, digoxin, droxidopa, or sodium oxybate (GHB) because the risk of severe drowsiness, breathing problems, seizures, irregular heartbeat, or heart attack may be increased

  • Naltrexone because it may decrease Histex HC Liquid's effectiveness

  • Bromocriptine or hydantoins (eg, phenytoin) because their side effects may be increased by Histex HC Liquid

  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Histex HC Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Histex HC Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Histex HC Liquid:


Use Histex HC Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Histex HC Liquid by mouth with or without food.

  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • If you miss a dose of Histex HC Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Histex HC Liquid.



Important safety information:


  • Histex HC Liquid may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Histex HC Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

  • Do not take diet or appetite control medicines while you are taking Histex HC Liquid without checking with your doctor.

  • Histex HC Liquid has pseudoephedrine in it. Before you start any new medicine, check the label to see if it has pseudoephedrine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.

  • Histex HC Liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Histex HC Liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

  • Histex HC Liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Histex HC Liquid for a few days before the tests.

  • Tell your doctor or dentist that you take Histex HC Liquid before you receive any medical or dental care, emergency care, or surgery.

  • Use Histex HC Liquid with caution in the ELDERLY; they may be more sensitive to its effects.

  • Caution is advised when using Histex HC Liquid in CHILDREN; they may be more sensitive to its effects.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Histex HC Liquid while you are pregnant. It is not known if Histex HC Liquid is found in breast milk. Do not breast-feed while taking Histex HC Liquid.

When used for long periods of time or at high doses, Histex HC Liquid may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Histex HC Liquid stops working well. Do not take more than prescribed.


When used for long periods of time or at high doses, some people develop a need to continue taking Histex HC Liquid. This is known as DEPENDENCE or addiction.


If you suddenly stop taking Histex HC Liquid, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; trouble sleeping.



Possible side effects of Histex HC Liquid:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor; trouble sleeping; vision changes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Histex HC side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Histex HC Liquid:

Store Histex HC Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Histex HC Liquid out of the reach of children and away from pets.


General information:


  • If you have any questions about Histex HC Liquid, please talk with your doctor, pharmacist, or other health care provider.

  • Histex HC Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Histex HC Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

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